V.MED - Drive 300 Matrix is part of the standard range of company products.

Overview and History of Drive

(225mg boldenone undecyleanate and 75mg methandriol dipropionate)

75 mg Methandriol Dipropionate

Methandriol is the brand name for the anabolic steroid methylandrostenediol. In this profile we will review the properties and usage of this drug for the athlete looking for an edge.

Methandriol (or MAD as I like to call it) seems to be one of the more rare and exotic anabolic steroids. It is actually 5-androstenediol (5AD) that has had its chemical structure modified by adding a methyl group so the compound can resist being broken-down by the liver when taken orally. This results in better utilization by the body and is called 17-alpha alkylation (17AA). The first aspect that will be addressed is the one that most interests bodybuilders, the muscle building potential of the drug. With an anabolic (muscle building) effect of 20-60 (compared testosterone which has an anabolic rating of 100), not much muscle gain can be expected from MAD use. It is also slightly androgenic, again when compared to testosterone which has an androgenic effect of 100 MAD only rates 30-60. Methandriol low androgenic properties may be a blessing and a curse, on one hand with its low androgenic effects the drug can be used without worries by prone individuals who suffer from prostate problems, hair loss and acne. It may also be used by female bodybuilders who wish to avoid the masculinizing side effects of androgens once they stick to a reasonable dosage and cycle duration.1 On the other hand the benefits of using an androgenic steroid are lost, there is a direct correlation between a drugs androgenic levels and strength gains, highly androgenic steroids also tend to aid in fat loss by binding strongly to the androgen receptor (A.R). So not much muscle or strength gain from this one. So what the hell is it good for? Glad you asked. Methandriol has been shown to have an affinity for glucocorticoid-binding sites(2) so this may result in an anti-catabolic (muscle destroying) effect by inhibiting the muscle wasting effects of glucocorticoid hormones(3) also the parent hormone of methandriol, 5-androstenediol (5AD) has been shown to promote favorable immune function(4). MAD is said to process a unique trait that no other steroid has, the ability to sensitize the androgen receptor (A.R) to other hormones or the ability to unblock the AR, I do not know how it started but this statement is untrue and very misleading, first the A.R does not get "clogged up", in fact all androgens increase the number of A.R in muscle tissue (5) so there is no need to use any specific steroid for this purpose. So far the report on methandriol does not look as good as other anabolic steroids, little muscle and strength gains, however it may boost immune function and activate other non-A.R dependant mechanisms of muscle growth. Adverse androgenic sides are also not a major concern.

Methandriols parent hormone 5AD has been shown to be a steroid with "potent estrogenic properties"(6), since methylation makes a hormone more bio-available and thus "stronger" I am lead to believe that methandriols estrogenic activity is even more potent than 5AD. This alone is bad news for any Steriod.com members interested in adding this drug to a cycle, excessive estrogenic activity can lead to breast tissue growth in men (gynecomastia), fat gain, water retention, loss of sex drive, and sluggish natural testosterone production. Worse still is that 5AD itself activates the estrogen receptor (E.R.)(6) This would make aromatize inhibitors like letrozole (femera) and anastrozole (arimidex) a bit less effective in combating MAD estrogenic sides because it does not have to be exposed to the aromatize enzyme to do any harm. More evidence that supports MAD has direct estrogenic properties is its use in veterinary injectables. Commonly used for promoting weight gain in animals(7), studies indicate combining anabolic steroids with female sex hormones (estrogen, progesterone) promote better weight gain that either alone(8)this especially holds true to when female sex hormones are stacked with the non-aromatizing nandrolone derivative trenbolone(9). MAD estrogenic properties would make it useful in this regard, this is the REAL reason MAD is added to other anabolic veterinary preparations, not because it sensitizes the A.R. Most of the profiles on methandriol says it gives "massive strength gains", however looking at the evidence it would seem the only "massive strength gains" from MAD could stem from the increased amount of water retention inside the muscles which would result in a rebound effect when the muscles are compressed during the lowering of a weight, similar to the action of a benching shirt. Believe or not estrogen is a muscle building hormone as well, causing growth by attaching to the estrogen receptor on muscles (10) these are minor benefits however and are not worth the potential adverse sides. A common trait from using MAD is elevated blood pressure (11) this could be from the water retention due to high estrogenic activity or other actions in the body (11) There is no evidence that methandriol negatively effects cholesterol so your cardio vascular heath would be the least of your worries if you chose to use methandriol.

Right, now that we know the properties of this drug, we can design cycles to take advantage of MAD. Dosages for MAD range from 30mg to 50mg per day, taken orally or by injection. Being a water based suspension the active life of the drug would be measured in hours thus methandriol must be injected at least everyday to keep steady blood levels of the active hormone, if you are to ever come across this drug in its water based form and did not want to inject it dont worry, remember its a 17AA compound so yes, YOU CAN DRINK METHANDRIOL. The same thing applies to the drug (oral administration) in tab from if you were to ever find it. Being a 17AA steroid it puts some strain on the liver when orally consumed, steroid.com members are advised to limit the drugs intake to several weeks. It is obvious that MAD is too weak to be used without stacking it with other steroids, and it is very common to find it included in various exotic steroid preparations. Keep in mind MAD itself has an estrogenic action so the appropriate precautions must be taken to combat this. Methandriol first must be stacked with testosterone, preferably a short ester one (see testosterone propionate). Testosterone will combat the libido lowering effects of MAD, as stated before estrogenic hormones like MAD seems to work best when combined with trenbolone so this would be the second anabolic of choice. Now you are going to need something to deal with methandriols estrogenic action, letrozole would be my first choice, it does not only block the aromatize enzyme, it reduces the concentrations of estrogen receptors as well (12), leaving MAD with less to bind to. Tamoxifen (novice) would also be a good addition to the letrozole, binding to what ever estrogen receptors are left. However, ancillary usage could negate many of methandriols benefits because they are seemingly are estrogen dependant!! Now the previously mentioned cycle looks like a cutting cycle, I did not design it to be one, its just that combining MAD with other highly aromatizing steroids or "bulking" drugs like dianabol, anadrol and long ester testosterones seems like asking for trouble. The level of water retention to follow would surely result in high blood pressure (not to mention the potential estrogenic side effects). I cannot recommend MAD be used with other bulking agents... In fact I do not recommend that methandriol be used at all!

Methandriol is a rare find in the hands of steroid.com members. An obscure anabolic that is reported to have special properties it simply does not have. Highly estrogenic and barely anabolic it is extremely doubtful this steroid will ever catch on in the steroid.com bodybuilding community.

225mg boldenone undecyleanate

Equipoise is the brand/trade name for the anabolic steroid Boldenone, which is an oil-based injectable anabolic steroid with the Undecylenate ester attached to it for a prolonged release rate and half-life. It is a derivative of Testosterone that retains Testosterone’s anabolic strength but exhibits a reduced androgenic effect in comparison. Equipoise is primarily a veterinary product, originally intended for use in animals. Equipoise has gained popularity with bodybuilders and athletes as a less androgenic form of Testosterone with less Estrogenic activity than Testosterone as well. Many users enjoy comparing it to that of Nandrolone (Deca Durabolin), however, this comparison is a very poor one seeing as though Nandrolone exhibits different properties than Equipoise and is also a totally different class of compounds (a 19-nor, also known as a progestin). However, many consider Nandrolone and Equipoise to be a solid substitute for one another in any given cycle.

A few interesting facts first about this compound: Equipoise was in fact developed in 1949, even before Dianabol (Methandrostenolone), making Equipoise technically the very first synthetic derivative of Testosterone even before Dianabol was ever thought of. Furthermore, Dianabol itself is actually Equipoise (Boldenone) with a methyl group attached to its 17-beta hydroxyl group on the steroid chemical structure (also known as C17-alpha alkylation) in order to allow it to become orally bioavailable in the body. Technically, Dianabol (Methandrostenolone) is actually C17-alpha alkylated Equipoise. It would have been considered an oral form of Equipoise, but the methylation at the 17th carbon atom changed enough of the properties of the compound that it was considered a totally different anabolic steroid analogue, and named Methandrostenolone (Dianabol). If pictures of the chemical structures of Equipoise and Dianabol were laid out side by side, one would easily be able to tell the exact same chemical structure between the two, with the exception of the methyl group affixed to the 17th carbon on the Dianabol chemical structure. It is very evident that these two anabolic steroids are essentially the exact same.

Although Equipoise was first developed in 1949, it was not until the 1960s when this compound would be finally released and marketed as Parenabol. Between 1949 and its release in the 1960s, Ciba had toyed around with Equipoise by attempting to affix different esters onto it in order to augment its half-life and release rates. The final conclusion was that it would be released with the Undecylenate ester attached to it, and the final preparation was that of Boldenone Undecylenate. Following the release of Parenabol, various clinical trials and testing of this compound was conducted in the late 1960s and early 1970s with the goal in mind to use it as a lean mass promoting and preserving anabolic steroid in order to treat individuals suffering from any condition in which wasting and weight loss were symptoms, as well as an osteoporosis treatment. Parenabol saw very little application or use following its release, and towards the end of the 1970s, it was removed from the market and discontinued.

Squibb would then pick up the patents for this anabolic steroid and re-release Boldenone under the name Equipoise as a veterinary anabolic steroid meant primarily for application in horses but is also intended for use in other animals. Equipoise is well known for its lean mass increases as well as its appetite-stimulant effects, which is an effect common among nearly all anabolic steroids. However, Equipoise tends to stimulate the appetite to far greater degrees than any other anabolic steroids. Although the manufacture and marketing of Equipoise has changed many hands over the years, it still remains available on the American market as well as internationally with plenty of generic brands as well as actual brand names available.

Chemical Characteristics of Equipoise

As previously mentioned, Equipoise is a synthetic derivative of Testosterone where it has been modified at carbon 1 and carbon 2 on the steroid structure, where double-bonds have been added between these two carbon atoms. This is what is known as the modification that is responsible for reducing Equipoise’s affinity for interaction with the aromatase enzyme (the enzyme responsible for the conversion of androgens into Estrogen). As a result, its Estrogenic activity is regarded to be lower than Testosterone. Equipoise is Boldenone with the Undecylenate ester attached to it. Specifically, ‘Undecylenate’ is Undecylenoic acid, but once bound to Boldenone it is properly referred to in chemistry as an ester bond (or ester linkage). Undecylenoic acid is chemically bonded to the 17-beta hydroxyl group on the Boldenone structure.  The addition of this ester augments the hormone’s release rate and half-life to favor a longer window of release. The primary reason for the augmentation of its half-life and release rate is because once Boldenone Undecylenate enters the bloodstream, enzymes work to break the bond between the ester and the hormone, which takes a varying amount of time. The end result is that of the ester being removed from the hormone by these enzymes, and the result following this is pure Boldenone that is free to do its work in the body. This process of enzymes removing the ester from the hormone to which it is attached is what is responsible for the slower release rates. When the Undecylenate ester is attached to Boldenone, creating Boldenone Undecylenate, the half-life of Boldenone is now extended to 14 days, providing a slower release and activity of the hormone than the hormone otherwise would without this ester.

Additionally, as noted near the beginning of this section, Equipoise and Dianabol are structurally identical with the only difference between the two being that Equipoise contains a the Undecylenate ester attached to its 17-beta hydroxyl group, and Dianabol instead contains a methyl group attached to its 17-beta hydroxyl group. Dianabol contains the methyl group (also known as C17-alpha alkylation) in order to prevent it from being metabolized and broken down by the liver through oral ingestion. Aside from these modifications, the two hormones are exactly identical and would be considered the exact same compounds. However, both of these hormones act significantly different from one another in the body, which is a very strong indication that the addition of a methyl group (C17-alpha alkylation) to the 17th carbon does more than just affect the hormone’s resistance to breakdown in the liver – it actually changes the effects and properties of the anabolic steroid.

Properties of Equipoise

Equipoise being a derivative of Testosterone grants it many of the same properties. For one thing, it possesses the exact same anabolic strength rating (100), and it is also an aromatizable anabolic steroid, which means that Equipoise can and does convert into Estrogen in the body through interaction with the aromatase enzyme. However, its double-bond modifications between carbons 1 and 2 reduce its affinity for the aromatase enzyme, granting it a lower rate of aromatization and therefore a lower Estrogenic activity in the body.

What this means is that Equipoise will still convert into Estrogen, but at a far less significant amount than its parent hormone Testosterone. Although this is a very comforting fact and a pleasing property, the issue of Estrogenic side effects is still an issue and should not be ignored by any users. Therefore, individuals can expect not an elimination of potential water retention, but a vast difference in a reduction of it from Equipoise alone. Although at sensible and moderate doses, Equipoise should not exhibit bloating or any other estrogenic effects (depending on user sensitivity), the risk of these Estrogenic side effects will indeed increase as higher and higher doses of Equipoise are used. Increasing doses will mean increased rates of aromatization of the anabolic steroid into Estrogen.

Equipoise itself possesses a low androgenic strength rating (lower than its progenitor hormone Testosterone), which should be pleasing to individuals whom are sensitive to any number of androgenic side effects. Overall, individuals utilizing Equipoise can expect the same anabolic size, strength, and mass gains that would come from Testosterone with a lower incidence of Estrogenic activity and androgenic side effects. This means that gains from Equipoise itself should, for the most part, be fairly solid lean mass gains with minimal water retention (depending on dose) and would be a perfect addition to any bulking or lean mass cycle. It would even work as an appropriate replacement for Nandrolone in any stack.

Equipoise Side Effects

As previously mentioned, Equipoise expresses a lesser degree of estrogenic activity in the body than Testosterone itself. Studies have demonstrated that approximately half of the aromatization rate is experienced in the body with EQ as compared with Testosterone. Thus, the magnitude of Estrogen-related side effects with Equipoise should be significantly lower than Testosterone, but it is important to note that its estrogenic activity is still higher than Nandrolone (Deca) by a small degree. Of course, if dosages rise, then aromatization (and subsequently, estrogenic effects) will rise in proportion. Usually Equipoise dosages rising above 200 – 400mg per week will result in observable increases in estrogenic side effects. Anti-estrogens and aromatase inhibitors may be necessary in these cases to stave off and ward off these side effects. Estrogenic side effects can include: water retention and bloating, increases in blood pressure (resultant from water retention), increased fat gain/retention, and potential development of gynecomastia.

Androgenic side effects, although much lesser than Testosterone, are still a possibility with Equipoise. Although Equipoise interacts with the 5AR (5-alpha reductase) enzyme, which is the enzyme responsible for the conversion of Testosterone into the stronger androgen DHT (Dihydrotestosterone), it does not convert into DHT but instead converts into Dihydroboldenone (DHB). Although it converts into DHB, studies have found Equipoise to undergo this conversion at a much lower rate than the conversion of Testosterone into DHT. Androgenic side effects can include: increased oily skin (sebum secretion), increased acne formation (linked to sebum secretion), bodily and facial hair growth, and the increased risk of experiencing male pattern baldness (MPB) if the individual possesses the genetic predisposition for it.

Equipoise is not liver toxic, and it does express the same degree of cardiovascular risks and endogenous Testosterone production suppression as most anabolic steroids.

Dosing and Administration of Equipoise

Medical Equipoise dosages and guidelines are nonexistent due to the fact that Equipoise is not currently approved for human use as a medicine. Although it was first utilized very briefly during the 1970s as a human grade medicine, this is no longer the case.

In the bodybuilding and athletic circles, beginner Equipoise dosages are generally in the range of 300 – 500 mg per week, followed by 500 – 700mg per week for intermediate dosages. Equipoise dosages are usually very similar to Testosterone, and venturing higher than the intermediate range is extremely rare, especially when the user is utilizing Equipoise alongside other compounds within a cycle, which should normally be the case.

Female anabolic steroid users might find Equipoise a suitable compound due to its considerably lower androgenic capabilities than Testosterone. In this case, females should find it acceptable to use 50 – 75mg per week. However, an issue that may present itself is Equipoise’s very long half-life of 14 days, which will undoubtedly manifest as a slow reduction of blood plasma levels. With this comes a slow elimination of the compound from the body, and this can be an issue when/if virilization signs and symptoms appear in female users and prompt discontinuation of the drug is paramount.

Being that its half-life is 14 days, it is ideal to split up the weekly dosage into two administrations spaced evenly throughout the week (for example, 500mg per week administered as 250mg on Monday and 250mg on Thursday).

Equipoise Cycles and Uses

EQ cycles are usually run as mass gaining cycles that always involve the use of at least Testosterone in some form (usually the long esters of Testosterone, in order to match-up with EQ’s half-life). This is usually done with either Testosterone Enanthate or Testosterone Cypionate. Equipoise cycles are also normally run for much longer cycle lengths than most other compounds, due to the fact that its longer half-life provides a slower release and peak-time for effects to be seen.

Beginner Equipoise cycles normally involve the use of Testosterone Enanthate (or Cypionate) at around 300 – 500mg per week alongside Equipoise at about 400mg per week. The cycle should be run for a total of 14 weeks. This should provide the user with a considerable amount of mass gains over the long term. Intermediate Equipoise cycles can involve the added use of an oral compound, usually Dianabol (Methandrostenolone) at about 25mg per day. Testosterone Enanthate (or Cypionate) in this case can be reduced to 100mg per week in order to merely maintain normal physiological function, and Equipoise can be run at about 400 – 600mg per week. The Dianabol in this case is run from weeks 1 – 4, and the total cycle length is 12 weeks.

Advanced Equipoise cycles usually do not see the use of EQ at dosages above 600mg per week. Much like the intermediate Equipoise cycles, Testosterone can be run at TRT (Testosterone Replacement Therapy) dosages of around 100mg per week, and an advanced compound can be used alongside everything, such as Trenbolone Enanthate at 400mg per week. Total cycle length would be 12 weeks.

Effective Dose (Men): 30-50mg orally (daily)/ 300-500mg injectable (weekly)

Effective Dose (Women):

Active life: 2-3 days

Detection Time: 3 months